The “less is more” theory is very popular among kratom forums, and there is some evidence to back this theory. Almost every strain has an optimal dose for both medicinal and euphoric effects, and dosage above this ideal threshold can have reverse effects due to mu opiod antagonists such as corynantheidine.

 

Now, it’s important to note that different strains have differing levels of this alkaloid, so this statement may not apply to all strains, however, the majority of strains are affected.

 

The “less is more” theory, is also advisable because lower dosage also creates less tolerance to effects, which can increase the plant’s medicinal potential over time.